Olfactory Neuroblastoma with Intracranial Extension

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Neoadjuvant chemotherapy in the setting of locally advanced olfactory neuroblastoma with intracranial extension

Olfactory neuroblastoma (esthesioneuroblastoma) is a rare malignant tumor of neuroectodermal origin. With only about 1,000 cases reported, there are no clear guidelines regarding management of this disease. Intracranial extension and orbital involvement have been shown to be independent risk factors associated with poorer outcomes. We hereby report a case of a 46-year old male presented with an...

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Intracranial olfactory neuroblastoma: evidence for olfactory epithelial origin.

AIMS To determine the possible histogenesis of the intracranial variant of olfactory neuroblastoma. METHODS Four specimens from three cases of intracranial olfactory neuroblastoma were studied by light microscopy and immuno-histochemistry, and electron microscopy in two cases. RESULTS Light microscopical examination showed small cell tumour with additional features of epithelioid cells in o...

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Olfactory neuroblastoma.

Few neoplasms are unique to the sinonasal tract, but sinonasal undifferentiated carcinoma and olfactory neuroblastoma are malignant tumors which require unique management. Due to the rarity of these tumors, practicing pathologists are not always aware of their distinctive clinical, radiographic, histologic, immunohistochemical, and molecular features. These cases are frequently submitted for co...

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Atypical Olfactory Neuroblastoma Presenting as Sinonasal Polyposis with Nasopharyngeal Extension: A Case Report

Background: Olfactory neuroblastoma also known as Esthesioneuroblastoma (ENB) is a tumor arising from the basal layer of olfactory epithelium in the superior recess of the nasal cavity in the region of cribriform plate. Incidence peaks once in 11 20 years of age and again in 50 60 years of age. It is equally found in men and women. Aim: The main aim of this case report is to characterize the cl...

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ژورنال

عنوان ژورنال: Neurologia medico-chirurgica

سال: 1989

ISSN: 0470-8105,1349-8029

DOI: 10.2176/nmc.29.902